BackgroundHuman pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show tremendous promise for cardiac regeneration following myocardial infarction (MI), but their transplantation gives rise to transient ventricular tachycardia (VT) in large-animal MI models, representing a major hurdle to translation.Our group previously reported that these a
WN editor Geoffrey Cannon writes: My hero in this issue is John Maynard Keynes, who a century ago gave clues to just how ominous world prospects are now.Then I ruminate on the overuse and abuse of the word 'we', as in 'Yes, we can', or 'We need to tackle the challenge of epidemic obesity'.Who are 'we'? Then some shoc
Abstract Background There is a significant push to change the trajectory of youth mental ill-health and suicide globally.Ensuring that young people have access to services that meet their individual needs and are easily accessible is a priority.Genuine stakeholder engagement in mental health system design is critical to ensure that system strengthe
In this paper we examine an Information-Theoretic method for solving noisy linear inverse estimation<em> </em>problems which encompasses under a single framework a whole class of estimation methods.Under this framework, the prior information about the unknown parameters (when such information exists), and constraints on the parameters c